new research from a New Jersey team, authored by Doctors Arnold Peckerman,
Benjamin Natelson et al., which found left-ventricular dysfunction
following exertion and orthostatic stress in patients with myalgic
encephalomyelitis/chronic fatigue syndrome. The WedMD article and the
press release are available at the link below. In an NIH-funded study on
impedance cardiography also linked below, Peckerman and Natelson found that
low cardiac output correlated with symptom severity in ME/CFS.
Dr. A. Martin
Lerner holds U.S. patents for the diagnosis of ME/CFS in the
chronic mononucleosis subset of this disease using 24-hour Holter
monitoring. He argues that a prominent subset of the disease is a
prolonged, chronic mononucleosis following infection with
Epstein Barr virus (EBV), Human Cytomegalovirus (HCMV), or both, and/or
possibly Human Herpes Virus 6 (HHV-6). Viral infection
persists in the heart, causing left-ventricular dysfunction, producing
exercise intolerance. Exercise, in turn, worsens the cardiac
dysfunction. He has also postulated that the disease is an early
dilated cardiomyopathy that in later stages might result in progressive,
end-stage dilated cardiomyopathy, a type of heart failure. Dilated
cardiomyopathy is sometimes viewed as "idiopathic," or "Idiopathic Dilated
Cardiomyopathy" (IDC). In an editorial response titled "Microbial
Persistence and Idiopathic Dilated Cardiomyopathy," Dr. Lerner has
postulated that these viruses may be the etiological link.
More recently, physicist, physician,
long-time ME/CFS researcher and clinician, and heart-transplant recipient
Paul Cheney, M.D., Ph.D., has offered an alternative theory that a subset
of ME/CFS patients suffer from a diastolic cardiomyopathy, a problem with
ventricular filling resulting from mitochondrial dysfunction and low ATP
energy in the heart.
To view a streaming video of a
three-hour talk by Dr. Cheney on diastolic cardiomyopathy and
ME/CFS, click here. This video can be accessed with a broadband connection only.
The video cannot be properly viewed using a dial-up modem.
Because there may be many people trying to access the video at once, our
server may become temporarily overloaded. Please try back again if
you encounter this problem or if the video does not play for the full
three hours. Note that some of the most informative parts of this
three-hour talk occur in the second half when Dr. Cheney discusses and
shows charts on cardiac output in litres per minute, comparing ME/CFS
patients with controls. To purchase a
videocassette of this seminar by Dr. Cheney from the Dallas-Fort Worth CFS group,
click here. A detailed discussion of Dr. Cheney's views
is available below in an interview by Carol Sieverling, and is recommended
reading along with the Peckerman/Natelson article on impedance
cardiography for those who want to study the
insightful issues addressed in the video. To purchase a DVD set of another talk by Dr. Cheney
illustrating more recent echocardiographic and other objective data on ME/CFS and heart failure, click here.
Some of Dr. Lerner's
significant articles, as well as his patent issued in 2002, are linked
below in Portable Document File (PDF) format. These files require an Adobe
Acrobat Reader. Most computers come with this program preloaded.
If not, a free Acrobat Reader can be downloaded