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C F S  - Information International     
 

Treatments  for  CFS / FM

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Pain relievers and vitamins/supplements are commonly used, jones.etal03.txt, jones.etal03.pdf. Complementary and alternative medicine (CAM) is also widely used, jones.etal.07.txt. Magnesium is essential, press.magnesium04.txt. D-Ribose, teitelbaum.etal06.txt, teitelbaum.etal06.pdf, and folinic acid, lundell.etal06.txt. Intraveneus treatment with nutritients, massey07.txt.

Normalization of leaky gut in CFS is accompanied by a clinical improvement, maes.leunis08.txt.

Rehabilitation of decreased motor performance in patients with CFS: should we treat low effort capacity or reduced effort tolerance?, van.houdenhove.etal07.txt, van.houdenhove.etal.07.txt, van.houdenhove.etal07.pdf.

Japanese research on CFS Treatments, japanese.treatments08.txt.

 

Drug Treatments

Summing up 4 drugs, hoseini.etal07.txt.

Raloxifen in treatment of fibromyalgia in menopausal women, sadreddini.etal08.txt

Gabapentin an upcoming drug for FM pain, arnold.etal07.txt, arnold.etal.nih07.txt, and arnold.etal.nfa07.txt.

Pregabalin [US brand name: Lyrica], arnold.etal.07.txt, and owen07.txt, and as augmentation for quetiapine therapy in FM, calandre.etal07.txt. Pregabalin, approved by the FDA for the treatment of FM, was shown to have an effect, mease.etal08.txt, pregabalin08.txt, arnold.etal08.txt.

 

Midodrine has been tested on one CFS patient’s autonomic nervous system symptoms, naschitz.etal04.txt, naschitz.etal04.pdf. Thorough studies have dismissed the drug Modafinil,  randall.etal05.txt, randall.etal05.pdf. A review on Modafinil, kumar08.txt.

 

Methylphenidate reduces symptoms in some CFS patients, blockmans.etal06.txt, blockmans.etal06.pdf.

 

Pramipexole has been tried, holman.myers05.txt. Mirtazapine (U.S. brand name: Remeron) in treating fibromyalgia, samborski.etal04.txt, samborski.etal.04.txt.

Influence of melatonin on fatigue severity in patients with CFS and late melatonin secretion, vanheukelom.etal06.txt, vanheukelom.etal06.pdf.

Antidepressant medicine has repeatedly shown to be ineffective, but these authors have had success, thomas.smith06.txt, thomas.smith06.pdf.

FM patients may benefit from antidepressants, arnold07.txt. Antidepressants in FM, uceyler.etal08.txt, Duloxetine in particular, uceyler.etal.08.txt. Duloxetine [US brand name: Cymbalta ®] for FM pain: systematic review of randomised trials, sultan.etal08.txt and russell.etal08.txt.

Amitriptyline in the treatment of FM: a systematic review of its efficacy, nishishinya.etal08.txt.

Milnacipran is an SNRI antidepressant that inhibits reuptake of both serotonin and norepinephrine, used for treatment of FM, dempsey08.txt. Milnacipran for the treatment of FM in adults, clauw.etal08.txt. Venlafaxine reverses CFS-induced behavioral, biochemical and neurochemical alterations in mice, dhir.kulkarni08.txt.

5-HT(3)-receptor antagonists, (the neuronal 5-HT(3) receptor network after 20 years of research) management of pain and inflammation, faerber.etal07.txt.

Exercise and pyridostigmine in the treatment of FM improves sleep, jones.etal07.txt.

Nabilone, a synthetic cannabinoid, skrabek.etal07.txt. Are cannabinoids a new treatment option for pain in patients with FM?, staud.koo08.txt. Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, FM, IBS and other treatment-resistant conditions?, russo08.txt.

Growth hormone (GH) treatment of FM, cuatrecasas.etal07.txt.

 

Surgery

Clinical evidence for cervical myelopathy due to Chiari malformation and spinal stenosis in a non-randomized group of patients with FM, heffez.etal04.txt and, heffez.etal07.txt.

  

Anestesia

Anaesthesia for patients with idiopathic environmental intolerance and CFS, fisher.rose.08.txt, fisher.rose08.txt, fisher.rose08.pdf.

 

CBT & Exercise

Most studies on exercise therapy have high drop-out numbers and short follow-up time (months). One study follows patients 6 months, but has low drop-out, pardaens.etal06.txt, pardaens.etal06.pdf.

A review: New Psychological Interventions in Chronic Illness: petrie.revenson05.txt. Can high "action-proneness" in patients with CFS be changed by a multidisciplinary group treatment, van.houdenhove.etal06.txt, van.houdenhove.etal06.pdf.  Is graded exercise better than CBT for fatigue?  ridsdale.etal04.txt.

A review concludes “pacing self-management techniques and pain neurophysiology education are indicated for the treatment of musculoskeletal pain in CFS patients”, nijs.etal06.txt, nijs.etal06.pdf.

Non-pharmacological intervention, jason.etal07.txt, jason.etal07.pdf.

 

Immunological treatments

Anakinra a recombinant interleukin-1 receptor antagonist, hoseini.gharibzadeh06.txt. A drug which supposedly influences natural killer cells (BioBran MGN-3) has no effect in CFS, mc.dermott.etal06.txt, mcdermott.etal06.pdf.  Staphylococcus Toxoid Vaccine, gottfries.etal06.txt, gottfries.etal06.pdf.

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission, maes.etal07.txt.

 

Effective pain palliation in FM patients with Botulinum Toxin type-A: Case series of 25, gordon.etal08.txt.

 

Antibiotics

One of the few studies published on the use of antibiotical treatment (azithromycin) in CFS, vermeulen.scholte06.txt.

Placebo

Placebo response has no major role in CFS treatment, cho.etal05.pdf. Distant healing, like placebo, have no effect, walach.etal08.txt.


 

Leucocyte Apheresis

Aphaeresis (i.e. depletion) of blood leucocytes (monocytes and granulocytes) in 4 CFS patients, a treatment which changes blood cytokine profile, boye.etal04.txt.

 

Herbs

Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus Zeylanicus (rats), tharakan.etal05.txt, tharakan.etal05.pdf. Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of CFS (mice), chen.etal.08.txt, chen.etal08.pdf.

 

Essential fatty acids etc.

One patient was cured from CFS (including improvement of brain structural changes) using fish oil tablets, puri.etal04.txt,  puri.etal04.pdf. Four other patients were better from use of essential fatty acids, puri04.txt, puri04.pdf. 

 

Acetyl- and propionylcarnitine has demonstrated benefits on general fatigue in an open study, vermeulen.scholte04.txt, vermeulen.scholte04.pdf. Double-blind trial comparing acetyl l-carnitine with placebo in the treatment of FM, rossini.etal07.txt.  Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue, malaguarnera.etal07.txt, malaguarnera.etal07.pdf.

 

Dr. Nicolson uses an extensive protocol of Lipid Replacement and Antioxidant Nutritional Therapy, nicolson.II.06.txt,   nicolson.ellithorpe06.txt.

 

Oxygen

Hyperbaric oxygen treatment has been suggested, vanhoof.et.al02.txt, and baltzan.etal05.txt.

 

Acupuncture

Acupuncture improves blood flow, sandberg.etal04.txt and sandberg.etal05.txt. Better than drug therapy (China), guo.sun05.txt. Useful in the treatment of headache, vickers.etal04.pdf.  Electro-Acupuncture for CFS, wang.xiong05.txt  and mears05.txt. Observation on therapeutic effect of multiple cupping at back-shu points on CFS, chen.etal08.txt. FM can also be treated with acupuncture, singh.etal06.txt, and singh.etal08.txt. Formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency, harris.etal05.txt. Acupuncture in FM, martin.etal06.txt, as well as in CFS has anti-fatigue effect, yuemei.etal06.txt.  No effect on FM by acupuncture concludes a review, mayhew.ernst06.txt. However, a more recent paper concludes that acupuncture appears to offer symptomatic improvement to some patients with FM, duncan.etal07.txt and staud07.txt.

 

A randomized controlled trial of acupuncture added to usual treatment for fibromyalgia, targino.etal08.txt.

Traditional chinese medicine for CFS should be investigated more, chen.et.al08.txt.

Transcranial Stimulation

Lymphatic drainage of the neuraxis in CFS: a hypothetical model for the cranial rhythmic impulse, perrin07.txt, perrin07.pdf. Transcranial stimulation in FM, fregni.etal06.txt, and passard.etal07.txt, and thimineur.deridder07.txt.

 

Hypnosis

The structure of the hypnosis session outlined, vallings05.txt, vallings05.pdf.

Biofeedback in FM, hassett.etal07.txt.

 

Thermal Therapy - Balneotherapy

A Japanese study has reported effect of thermal therapy in 2 (two) CFS patients, masuda.etal05.txt.

 

FM can be treated with heat, donmez.etal05.txt, and balneotherapy has shown effects on cytokine parameters, ardic.etal06.txt. The effectiveness of hydrotherapy in the management of fM: a systematic review, mcveigh.etal08.txt.
 


 
 

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