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Cognitive Behavioral Therapy  &  FM/ CFS

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CBT – cognitive behavioural therapy

CBT aims “to establish a new equilibrium”, vanhoudenhove06.txt, vanhoudenhove.etal06.txt.

 

A theoretical and empirical review, deary.etal07.txt,  deary.etal.07.txt,  deary.etal07.pdf. In CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS, caseras.etal08.txt, caseras.etal08.pdf.

 

Personality styles in patients with FM, major depression and healthy controls, nordahl.stiles07.txt. Personality profiles in CFS patients, le.bon.etal07.txt, le.bon.etal07.pdf. 

 

According to strong advocates for CBT, a cultural component underlies CFS, cho.etal08.txt, cho.etal.08.txt, cho.etal08.pdf.

 

A remarkable finding ‘Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with CFS’, delange.etal08.txt, delange.etal.08.txt, delange.etal08.pdf.

 

Another therapy has evolved: Mindfulness-based stress reduction (MBSR) a systematic program for reduction of suffering associated with a wide range of medical conditions, FM included, grossman.etal07.txt

Limitations to psychotherapy, moloney06.txt.

 

CBT and CFS

A BMJ-review concluded that CBT (in combination with graded exercise) was the only documented treatment for CFS,  Reid et al., 2000.  A letter of response,  Chaudhury, 2000.  Also the NICE guidelines for ME/CFS recommends CBT, leaving UK patient organizations in agony, meresearch.uk.comment06.txt.

CBT in a hospital setting,  Agaki et al., 2001 (txt),  Agaki et al., 2001 (pdf), was criticized for patients having been recruited on criteria not strictly fulfilling the CDC criteria, and for using wrong WHO disease code,  letter, Agaki, 2001.  A 5-year follow-up study concluded that CBT was better than relaxation therapy, but was no cure for CFS,  Deale et al., 2001.  Senior CFS researchers conclude that CBT is helpful but no cure for CFS,  Evengard & Klimas, 2002.

Implementing CBT for CFS in a mental health center, scheeres.etal07.txt, scheeres.etal.07.txt, scheeres.etal07.pdf.  Implementing CBT for CFS in mental health care: a costs and outcomes analysis, scheeres.etal08.txt, scheeres.etal.08.txt.

The Canadian clinical CFS work definition includes a discussion of studies on CBT,  Carruthers et al., 2003.

Most surprisingly to many a Dutch study, performed by experts in the field, concluded that CBT made CFS patients worse, koolhaas.etal08.txt.

A Cochran review: CBT is effective in reducing the symptoms of fatigue at post-treatment compared with usual care, and may be more effective in reducing fatigue symptoms compared with other psychological therapies. The evidence base at follow-up is limited to a small group of studies with inconsistent findings. There is a lack of evidence on the comparative effectiveness of CBT alone or in combination with other treatments, and further studies are required to inform the development of effective treatment programmes for people with CFS,  price.etal.08.txt,  price.etal08.txt, price.etal08.pdf.

Hypocortisolism in CFS is potentially reversible by CBT, roberts.etal08.txt, roberts.etal.08.txt, roberts.etal08.pdf.

 

The PACE Trial

The comprehensive UK trial PACE [CBT and graded exercise] critized by patient groups, MCR.PACE.trial.scandal04.txt. The protocol for this trial, white.etal07.txt, white.etal.07.txt.

CBT is by no means a cure for CFS, vanhoof03.txt.  The therapists found it more difficult to treat patients with CFS than patients with psychological or other physical problems, bazelmans.etal04.txt.  A Dutch thesis on CBT and CFS, bazelmans04.pdf. A moderate effect on fatigue but no effect on functional disability, bazelmans.etal05.txt, bazelmans.etal05.pdf. The effect of CBT is no different in CFS with or without psychiatric diagnosis, prins.etal05.pdf.


Group CBT did not significantly improve cognitive function, quality of life, employment status or healthcare utility measures, odowd.etal.06.txt, odowd.etal06.txt.

CBT may result in patients feeling more able, but neuropsychological test results do not improve, knoop.etal07.txt, knoop.etal07.pdf.  These same authors conclude that ‘full recovery’ from fatigue takes place in 21% of patients. This study has no follow-up after CBT, knoop.et.al07.txt, knoop.et.al07.pdf. According to the authors CBT is effective for pain also, knoop.etal.07.txt, knoop.etal.07.pdf.

Self-instruction, instead of CBT, works well, knoop.etal08.txt, knoop.etal08.pdf, knoop.tables08.pdf .

CBT – Cost Effectiveness

When asked about treatments English CFS/ME patients counted CBT as the least effective,  CBT, Jones, 2003.  A recent Dutch study concluded that CBT is not effective when practiced by general practitioners, huibers.etal04.txt, huibers.etal04.pdf.  Another study could not document that CBT is cost-effective, severens.etal04.txt,  severens.etal04.pdf.  A ‘letter to the editor’ on this paper, letter.stouten04.pdf.  Cost-effectiveness of CBT in the treatment of chronic fatigue (CF) in primary care is equal to or higher than graded exercise therapy, when the main outcome measure was improvements in fatigue, mccrone.etal04.txt.

CBT delivered by GPs is not effective in the long term, leone.etal06.txt. A meta-analysis concluded that CBT for CFS tends to be moderately efficacious, malouff.etal07.txt, malouff.etal07.pdf.

CBT and FM

The respected Chicago CFS research group in a comprehensive 2001-review argued for the beneficial effect of CBT for both CFS and FM,  Friedberg & Jason, 2001 (short),   Friedberg & Jason, 2001 (paper).  A study, where fitness training was combined with CBT, found this to improve physical functioning in 25% of the patients,  Williams et al., 2002,  CBT works equally well for low back pain as for FM, wells-fedennan.etal03.txt.


CBT and exercise has only short term effect in FM, redondo.etal04.txt.  Four CBT programmes compared in Sweden: No major differences could be found between the programmes, henriksson.etal04.txt.

 

CFS subgroups

In a UK-multicentre study CBT proved better than guided support, but with rather high fall-out numbers,  Prins et al., 2001.  This article resulted in several "letters to the editor",  letters, Lancet, 2001.  

 


 
 

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Mette Marie Andersen, MD