Personality Profile of Patients with Chronic Fatigue Syndrome J of Chronic Fatigue Syndrome, Vol. 14(1) (2007), pp. 55-68 Olivier Le Bon MD, PhD [1, *], Bernard Cappeliez MD [1], Daniel Neu MD[1], Luc Stulens MSN [1], Guy Hoffmann PhD [1], Michel Hansenne PhD [2], Luc Lambrecht MD, PhD [3], Marc Ansseau MD, PhD [2], Paul Linkowski MD, PhD [1] Affiliations: [1] Brugmann University Hospital, Department of Psychiatry, Université Libre de Bruxelles, Belgium [2] University Hospital Liége, Department of Psychiatry, Université de Liége, Belgium [3] University Hospital Gent, Department of Internal Medicine, Gent, Belgium [*] Corresponding Author: Olivier Le Bon, CHU Brugmann Service de Psychiatrie, Plaza A. Van Gehuchten, 1020 Brussels, Belgium E-Mail: Personality may play a role in the predisposition, the precipitation and/or the maintenance of the CFS. Thirty-six consecutively examined female patients hospitalised for a sleep workup, filled out a Temperament and Character Inventory (TCI) questionnaire. A MANOVA compared the patients with a control group of females matched for age. Significant scores were obtained for dimensions such as Harm Avoidance, Reward Dependence, and Self-Directedness. However, the only subdimension of Harm Avoidance that proved significantly higher in CFS than in controls was "Fatigability," which is likely to overlap with the core CFS symptom. All in all, the personality structure does not appear to play a major role in the CFS. Keywords: Personality, chronic fatigue syndrome, TCI