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CFS and Depression
A
systematic review (MEDLINE search) of CFS: Don't assume it's depression, griffith.zarrouf08.txt, griffith.zarrouf.08.txt,
griffith.zarrouf08.pdf. Statistically
major depression (MD) and CFS do have an association, patten.etal05.txt. According to the CDC, ’CFS subjects
did not demonstrate any unique patterns of psychiatric disorders. MDD may not
be an important predisposing factor for CFS or the other fatiguing
illnesses’, axe.etal04.txt, axe.etal04.pdf.
English psychiatrist Dr. Sharpe is vigorously striving to embrace
CFS/ME in the psychiatric domaine, he suggests depression/CFS as one
diagnostic disease entity, sharpe05.pdf. According
to English psychiatrists self-diagnosed CFS/ME patients have high background
rate of depression, harvey.etal07.txt, harvey.etal07.pdf. Fatigue and depression are independently related to disability in
those with CFS, hadlandsmyth.vowles08.txt,
hadlandsmyth.vowles08.pdf. Depression,
CFS, and FM: An update, kaufman.goodnick06.txt,
kaufman.goodnick06.pdf. Statistically comorbidity
of FM and psychiatric disorders do exist, arnold.etal06.txt.
From
Canada: Factors
associated with depression among individuals with CFS: findings from a
nationally representative survey, fuller-thomson.nimigon08.txt,
fuller-thomson.nimigon08.pdf.
Differential diagnosis of CFS
and major depressive disorder, hawk.etal06.txt, hawk.etal06.pdf. Both
the MD and CFS patients demonstrated an overall fine motor slowing, with the
motor component being more affected in the MD patients, while both patient groups
showed similar cognitive impairments, schrijvers.etal08.txt,
schrijvers.etal.08.txt, schrijvers.etal08.pdf. Use of depression rating scales
in CFS, henderson.tannock05.pdf. Unexplained fatigue and
depression might act as independent risk factors for each other, according to
a statistical study using data from the WHO collaborative study of psychological
problems in general health care, skapinakis.etal04.txt,
skapinakis.etal04.pdf. Electrodermal dissociation of
chronic fatigue and depression: Evidence
for distinct physiological mechanisms,
news.pazderca-robinson04.txt,
pazderka-robinson.etal04.txt, pazderka-robinson.etal04.pdf. Depression in FM
The relationship between FM and depression, Okifuji et al., 2000. The
relationship between FM and major depressive disorder: a comprehensive review, pae.etal08.txt.
A 2000-meta-analysis [review of published studies]
of treatment of FM with anti-depressive medicine concluded, that it was
effective in reducing pain,
O'Malley et al., 2000, whereas a later study
concluded that placebo was just as effective, Heymann et al., 2001. Electroconvulsive therapy in FM patients with
depression only worked against the depression, leaving FM symptoms unchanged,
huuhka.etal04.txt. Depression and fibromyalgia: treatment and cost when
diagnosed separately or concurrently, robinson.etal04.txt.
A study consistent with the hypothesis that FM is a depression spectrum disorder,
in which FM and MDD are characterized by shared, familially mediated risk
factors, raphael.etal04.txt. Depression and Cytokines
Medical disease may cause
depression, something which may be the result of cytokines/immunological
activity, Iserson, 2000. Belgian researchers point at atypical
depression being intrinsic to the acute phase response and thus a part of CFS
physiology,
van Hoof et al., 2003, van Hoof et al., 2003 (pdf).
Suggested Treatments
An open study of 3
antidepressants over 6 months in CFS revealed no particular agent to be
better than others, but a "beneficial clinical effect" from
all, Janu, 2002. Recent
studies also point to antidepressants being useful for many somatic
conditions other than CFS and FM, Allgulander & Kasper, 2002. Anti-depression medication helped, but
sample size was limited and the study design not double-blind or placebo
controlled, amsterdam.etal07.txt, amsterdam.etal07.pdf. |
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