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C F S  - Information International     
 

Depression  &  CFS/ FM

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CFS and Depression

A systematic review (MEDLINE search) of CFS: Don't assume it's depression, griffith.zarrouf08.txt,  griffith.zarrouf.08.txt, griffith.zarrouf08.pdf.

 

Statistically major depression (MD) and CFS do have an association, patten.etal05.txt.  According to the CDC, ’CFS subjects did not demonstrate any unique patterns of psychiatric disorders. MDD may not be an important predisposing factor for CFS or the other fatiguing illnesses’, axe.etal04.txt, axe.etal04.pdf.  English psychiatrist Dr. Sharpe is vigorously striving to embrace CFS/ME in the psychiatric domaine, he suggests depression/CFS as one diagnostic disease entity, sharpe05.pdf. According to English psychiatrists self-diagnosed CFS/ME patients have high background rate of depression, harvey.etal07.txt, harvey.etal07.pdf. Fatigue and depression are independently related to disability in those with CFS, hadlandsmyth.vowles08.txt, hadlandsmyth.vowles08.pdf.

 

Depression, CFS, and FM: An update, kaufman.goodnick06.txt, kaufman.goodnick06.pdf. Statistically comorbidity of FM and psychiatric disorders do exist, arnold.etal06.txt.

 

From Canada:

Factors associated with depression among individuals with CFS: findings from a nationally representative survey, fuller-thomson.nimigon08.txt, fuller-thomson.nimigon08.pdf.


The personality of CFS: vangeelen.et.al07.txt, vangeelen.etal07.txt, vangeelen.etal07.pdfCFS and DSM-IV personality disorders, courjaret.etal08.txt, courjaret.etal08.pdf.

 

Differential diagnosis of CFS and major depressive disorder, hawk.etal06.txt, hawk.etal06.pdf.  Both the MD and CFS patients demonstrated an overall fine motor slowing, with the motor component being more affected in the MD patients, while both patient groups showed similar cognitive impairments, schrijvers.etal08.txt, schrijvers.etal.08.txt, schrijvers.etal08.pdf.
 

 

Use of depression rating scales in CFS, henderson.tannock05.pdf.

 

Unexplained fatigue and depression might act as independent risk factors for each other, according to a statistical study using data from the WHO collaborative study of psychological problems in general health care, skapinakis.etal04.txt, skapinakis.etal04.pdf.

 

Electrodermal dissociation of chronic fatigue and depression:  Evidence for distinct physiological mechanisms,  news.pazderca-robinson04.txt, pazderka-robinson.etal04.txt, pazderka-robinson.etal04.pdf.

 

 

Depression in FM

The relationship between FM and depression, Okifuji et al., 2000.  The relationship between FM and major depressive disorder: a comprehensive review, pae.etal08.txt.

A 2000-meta-analysis [review of published studies] of treatment of FM with anti-depressive medicine concluded, that it was effective in reducing pain,  O'Malley et al., 2000,  whereas a later study concluded that placebo was just as effective,  Heymann et al., 2001.

Electroconvulsive therapy in FM patients with depression only worked against the depression, leaving FM symptoms unchanged, huuhka.etal04.txt.

Depression and fibromyalgia: treatment and cost when diagnosed separately or concurrently, robinson.etal04.txt. A study consistent with the hypothesis that FM is a depression spectrum disorder, in which FM and MDD are characterized by shared, familially mediated risk factors, raphael.etal04.txt.

 

Depression and Cytokines

Medical disease may cause depression, something which may be the result of cytokines/immunological activity,  Iserson, 2000.  Belgian researchers point at atypical depression being intrinsic to the acute phase response and thus a part of CFS physiology,  van Hoof et al., 2003,   van Hoof et al., 2003 (pdf).


A thesis from Sweden concludes that depression may be caused by mitochondrial dysfunction, gardner.thesis04.pdf.

 

Suggested Treatments

An open study of 3 antidepressants over 6 months in CFS revealed no particular agent to be better than others, but a "beneficial clinical effect" from all,  Janu, 2002.  Recent studies also point to antidepressants being useful for many somatic conditions other than CFS and FM,  Allgulander & Kasper, 2002.  Anti-depression medication helped, but sample size was limited and the study design not double-blind or placebo controlled, amsterdam.etal07.txt, amsterdam.etal07.pdf. 

 

 


 
 

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Mette Marie Andersen, MD