Original article Well-being in patients with chronic fatigue syndrome: The role of acceptance Journal of Psychosomatic Research, Vol 61, Issue 5, Nov 2006, Pages 595-599 doi:10.1016/j.jpsychores.2006.04.015 Stefaan Van Damme [a], Geert Crombez [a], Boudewijn Van Houdenhove [b], An Mariman [c], and Walter Michielsen [c] Affiliations: [a] Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium [b] University Hospital, Leuven, Belgium [c] University Hospital, Ghent, Belgium Received 6 December 2005; revised 6 April 2006; accepted 25 April 2006. Available online 1 November 2006. Abstract Objective: Research in chronic pain patients has shown that accepting the chronic nature of their illness is positively related to quality of life. The aim of this study was to investigate whether acceptance is also associated with better well-being in patients suffering from chronic fatigue syndrome (CFS). Methods: Ninety-seven patients completed a battery of questionnaires measuring fatigue, functional impairment, psychological distress, and acceptance. Results: Results indicated that acceptance has a positive effect upon fatigue and psychological aspects of well-being. More specifically, acceptance was related to more emotional stability and less psychological distress, beyond the effects of demographic variables, and fatigue severity. Conclusion: We suggest that promoting acceptance in patients with CFS may often be more beneficial than trying to control largely uncontrollable symptoms. Keywords: Chronic fatigue syndrome; Quality of life; Acceptance; Illness cognitions