Short report Alcohol use in chronic fatigue syndrome Journal of Psychosomatic Research, Volume 56, Issue 2, February 2004, pp 203-206 James Woolley, Roz Allen and Simon Wessely [*] Academic Department of Psychological Medicine, Guy's, King's & St Thomas's School of Medicine and Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF, UK [*] Corresponding author. Tel.: +44-20-7848-0448; fax: +44-20-7848-5129 Received 4 December 2001; accepted 22 January 2003. Available online 4 March 2004. Abstract Objective: To examine the anecdotal observation that patients with chronic fatigue syndrome develop alcohol intolerance. Methods: A consecutive case series of 114 patients fulfilling UK criteria for chronic fatigue syndrome referred to a specialist clinic. Self-reported alcohol use pre- and postdiagnosis, fatigue symptoms and comorbidity measures were collected. Results: Two-thirds reduced alcohol intake. The most common reasons were increased tiredness after drinking (67%), increased nausea (33%), exacerbated hangovers (23%) and sleep disturbance (24%). One-third of the subjects also stopped drinking because "it seemed sensible." Some had been advised to avoid alcohol, but the majority (66%) did so on the basis of personal experience. Conclusion: Our data supports the anecdotal belief that chronic fatigue syndrome patients reduce or cease alcohol intake. This is associated with greater impairment in employment, leisure and social domains of function, and may hint at psycho-pathophysiological processes in common with other conditions that result in alcohol intolerance. Author Keywords: Alcohol; Chronic fatigue syndrome; Impairment; Neurasthenia; Symptom; Intolerance Copyright © 2004 Elsevier Inc. All rights reserved.