Guest Editorial: Suffering, Science and Sabotage J of Musculoskeletal Pain, Vol. 12(2) 2004, pp. 3-18 Muhammad B. Yunus, MD Muhammad B. Yunus, MD, is Professor of Medicine, Section of Rheumatology, University of Illinois College of Medicine at Peoria E-mail: yunus@uic.edu Address correspondence to: M. B. Yunus, MD, UICOM-P, One Illini Drive, Peoria, IL 61605. ABSTRACT. Objectives: The objective of this paper is to discuss suffering in general, the criticism against fibromyalgia and other central sensitivity syndromes [CSS], the deleterious effects of disease-illness dualism, a new unifying paradigm for this duality, and then to suggest a remedial model for better patient care. Methods: A review of the literature using Medline and other sources, and an amalgamation of known knowledge with author's own ideas and inquiry. Results: Bias against CSS are harbored by many physicians, thwarting the progress for a better understanding and treatment of these syndromes. Most physicians believe in disease-illness dichotomy and pay more attention to the structural than the functional pathology, e.g., neurochemical endocrine [NCE] abnormalities. Both types of pathology are likely based on biology. Even psychosocial distress is mediated by neurochemistry. A model is suggested for proper care where patients and physicians work together with a common satisfying goal, each fulfilling their individual responsibilities. Conclusion: Most physicians treat CSS with a negative attitude. The outdated model of disease-illness dualism should be abandoned in favor of a fresh approach to medical education that fosters compassionate care irrespective of the disease label. KEYWORDS. Suffering, disease-illness dualism, phenomenology, biology, compassionate care Medicine, the only profession that labors incessantly to destroy the reason for its own existence. -James Bryce © 2004 by The Haworth Press, Inc. All rights reserved.