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C F S
- Information International CFS and COI / NMH
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COI and CFS
Postural orthostatic tachycardia syndrome is an under-recognized
condition in CFS, hoad.etal.08.txt, hoad.etal08.txt, hoad.etal08.pdf. Higher heart rate at night in CFS, boneva.etal07.txt.
Small-heart
syndrome in CFS, miwa.fujita.08.txt. A review on orthostatic
intolerance in CFS/ME, spence.stewart04.pdf.
Orthostatic instability was similar in persons with CFS and nonfatigued
controls, jones.etal06.txt,
jones.etal06.pdf,
a result questioned, rowe.lucas07.txt. Dysautonomia-associated fatigue in CFS, newton.etal07.txt,
newton.etal07.pdf. On CFS exercise intolerance, Behan et al., 2001. Dr. Bell, an
expert in this area, recommends this procedure, Bell, procedure, 2000. The hemodynamic instability in CFS, Naschitz et al., 2001, Naschitz et al., 2002, including
fractal analysis,
Naschitz et al., 2003, Naschitz et al., 2003 (pdf). Dysautonomia is caused by shortened QT
interval, naschitz.etal.06.txt, naschitz.etal.06.pdf. Another group found autonomic instability
in CFS, but atributed this to deconditioning,
winkler.etal04.txt, winkler.etal04.pdf. Blood flow instability lowers oxygen delivery to
muscles, but this does not influence muscle metabolism in CFS, mccully.etal03.txt, mccully.etal03.pdf. Hypotension in early adulthood may predict
idiopathic CF later in life, lucas.etal04.txt.
Autonomic Nervous System in FM
Cutaneous microvascular circulation was normal in
FM, Al-Allaf et al., 2001. However, an interesting finding was made by
Swiss researchers, ‘Microcirculation abnormalities in patients with
fibromyalgia measured by capillary
microscopy and laser fluxmetry’, morf.etal05.txt. Abnormalities of Cardiovascular Neural Control
and Reduced Orthostatic Tolerance in Patients with Primary Fibromyalgia, furlan.etal05.txt. COI in FM versus CFS
One study measured OI in FM and
CFS and found a difference,
Naschitz et al., 2001. According to these researchers
there is no specific cardiovascular reactivity pattern in FM, naschitz.etal05.txt. Patients with Lupus
have COI (also named NMH), but this symptom was not a significant determinant
for bad health if patients simultaneusly had FM, tang.etal04.txt.
The Tilt Table Test
A head-up-tilt-test (CHUTT) has proven reliable with
CFS patients,
Naschitz et al., 2000, and an "instability
score" for CFS problems found with this test, Naschitz et al., 2002, and Naschitz et al., 2003. Patterns of hypocapnia
on tilt in patients with FM, CFS, nonspecific dizziness, and neurally
mediated syncope, naschitz.etal06.txt, naschitz.etal06.pdf.
In a COI in Adolescents and Children
Low erythrocyte volume combined
with COI,
Streeten et al., 2000. A very thorough study demonstrated attenuated
vasovagal reflexes behind POTS and CFS to be the same in adolescents, Stewart, 2000. Dr. Julian
Stewart also wrote this review on OI in CFS, Stewart, 2001, Stewart, 2001 (pdf). A study of cerebral functioning concluded that fatigue
is linked to orthostatic intolerance,
Tanaka et al., 2002, a matter discussed in
the journal,
editorial, Rowe, 2002, editorial, Rowe, 2002 (full paper). A Matched Case Control Study of OI in
Children/Adolescents With CFS, galland.etal07.txt,
galland.etal07.pdf. The Cause of COI in CFS
There is evidence for increased cholinergic
sensitivity in CFS,
Spence et al., 2000. An interesting study
on a possible defect in venous innervation as the cause of CFS-COI, Streeten, 2001. Newer studies found more substantial
evidence for the cholinergic thesis, kawamura.etal03.pdf,
khan.etal.03.txt, khan.etal03.txt, khan.etal03.pdf,
including the discovery of autoantibodies against cholinergic receptors, tanaka.etal03.txt. Further evidence for a difference
between CFS and GWS in relation to cholinergic response, khan.etal04.txt, khan.etal04.pdf
and spence.etal04.txt, spence.etal04.pdf. The A Norwegian group studied sympathetic predominance
of cardiovascular regulation, wyller.etal07.txt,
wyller.etal07.pdf and abnormal
thermoregulatory responses in adolescents with CFS: Relation to clinical
symptoms, wyller.etal.07.txt, wyller.etal.07.pdf. Also during orthostatic
stress and isometric exercise, wyller.et.al07.txt,
wyller.et.al07.pdf. The vascular instability in conditions like CFS is posibly
caused by autoantibodies (vasoactive neuropeptide autoimmunity), staines06.txt, staines06.pdf. Ortostatic
hypocapnia disturbes test results in a subgroup, natelson.etal.07.txt,
natelson.etal07.txt. Baroceptors in CFS
Baroceptor studies have revealed interesting results
in CFS, peckerman.etal03.txt, peckerman.etal03.pdf and peckerman.etal.03.pdf. |
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