J Hypertens. 2004 Apr;22(4):691-5. 

Prospective association between hypotension and idiopathic chronic
fatigue.

Lucas KE, Rowe PC, Coresh J, Klag MJ, Meoni LA, Ford DE.

Bloomberg School of Public Health and School of Medicine, Johns
Hopkins University, Baltimore, Maryland 21205-2233, USA.

OBJECTIVE: To determine whether there is an association between
hypotension and incident cases of idiopathic chronic fatigue.

DESIGN: A prospective study.

SETTING: Johns Hopkins Precursors Study.

PARTICIPANTS: Medical students (n = 876) in graduating classes from
1948 to 1964.

MAIN OUTCOME MEASURE: 'Easy fatigability' reported by
participants at 5- or 10-year follow-up after graduation. 

RESULTS: The unadjusted risk in women was 5.0 (95% exact confidence 
interval =1.4 to 17.4) and in men was 1.7 (95% exact confidence 
interval = 0.8, to 3.5).

CONCLUSION: These preliminary findings suggest that hypotension 
may be a risk factor for the development of idiopathic
chronic fatigue in women.

PMID: 15126909