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C F S
- Information International Cytokines
and CFS/ FM
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Cytokines
Cytokines are mediators of immune
activation. One particular cytokine, tumor
necrosis factor-alpha (TFN-alpha) produces an illness
resembling CFS (fatigue, cognitive complaints, pain, sleep disturbance and
depression), raison.etal05.txt and capuron.etal08.txt. Overproduction of this
particular cytokine may explain CFS, birchler.etal.press07.txt.
TFN-alpha has been linked to
Alzheimer’s disease, tobinick07.txt and
has profound influence on circadian sleep-regulation, cavadini.etal.press07.txt. Cytokines & CFS /FM symptomsCytokines are involved in
symptoms connected with physical exercise, Shephard, 2002.
At a 2001-meeting the CDC concluded
that the overproduction of cytokines may be the cause of CFS symptoms, cytokines.overprod01.txt. A
later study concludes the opposite: Postinfective fatigue syndrome is Not
associated with altered cytokine production, vollmer-conna.etal07.txt, vollmer-conna.etal07.pdf. Most
recently, data show for the first time in ME/CFS a cytokine and chemokine
profile, which suggests a TH17 shift in subgroups of a cohort, lombardi.etal08.txt. Plasma cytokine fluctuations
over time in healthy controls and patients with FM: These changes toward anti-inflammatory predominance
in FM may explain their common complaint of disturbed sleep because these
cytokines are known to disrupt sleep, togo.etal08.txt Although cortisol responses to
stress were normal, pro-inflammatory cytokine levels in CFS patients were
significantly attenuated, gaab.etal04.txt, gaab.etal04.pdf. In a pilot study on the effect
of activity and exercise, elevated concentrations of plasma transforming
growth factor beta (TGF-ß) was found, white.etal05.txt,
white.etal05.pdf. Cytokines
correlate with FM symptoms, bazzichi.etal07.txt.
tander.etal07.txt. Serum
ghrelin levels but not GH, IGF-1 and IGFBP-3 levels are altered in patients
with FM, tander.etal07.txt. An Increased
levels of neurotrophins are not specific for chronic migraine: Evidence from
primary FM, sarchielli.etal07.txt. Analysis
of pro- and anti-inflammatory cytokine production in severely fatigued
adolescents compared to individuals with CFS, ter.wolbeek.etal07.txt,
ter.wolbeek.etal.07.txt, ter.wolbeek.etal07.pdf. Parvovirus and hep C mimic CFS/ FMSymptoms caused by certain
cytokins occuring in connection with viral infections resembles CFS /FM, e.g.
parvovirus B19, kerr.tyrrell03.pdf, and hepatitis C, thompson.barkhuizen03.pdf.
INF-alpha-induced motor slowing is associated with increased depression and
fatigue in patients with chronic hepatitis C, majer.etal.08.txt
Pain and cytokines
Widespread pain may be
correlated with reduced antiinflammatory cytokines, uceyler.etal06.txt. Fatigue and cytokines
The connection of fatigue with
a group of cytokines, type I interferons, Englebienne et al., 2003 (short), Englebienne et al., 2003 and Englebienne et al., 2003 (pdf). Cytokines in blood cells
No increased production of IL-6 and IL-1b in monocytes, Kashipaz et al., 2003. Increased sensitivity to DHEA-inhibited Il-10
production in CFS cell cultures,
Visser et al., 2001. A Turkish 2002-study found IL-8 increased
in FM and related to pain intensity, Gur
et al., 2002. High levels of type 2 (Il- 4) cytokine-producing
cells
was found in CFS, skowera.etal04.txt, skowera.etal04.pdf. Similarly, CFS patients
showed significantly lower mRNA levels and (TGF-beta1) production, tomoda.etal05.txt, tomoda.etal05.pdf. Cytokines in nasal fluids and skin
One study found no indication
of inflammation in CFS sinuitis, Repka-Ramirez etal., 2002. However, locally in skin
activated cytokines are found in many FM patients, Salemi et al., 2002. Cytokines tested for treatment
Results on Il-6 treatment of
FM, Torpy et al., 2000. Il-6
treatment of CFS patients offered no improvement of cognitive
functioning,
Arnold et al., 2002.
Varies studies on CFS & cytokines
Dr. Natelson's group in New Jersey, reviewed studies
on cytokines in CFS using the neural-network classifiers, and found that one
cytokine (Il-4) made a difference,
Hanson et al., 2001. |
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