Date sent: Wed, 1 May 2002 A Randomized Controlled Trial of Muscle Strengthening versus Flexibility Training in Fibromyalgia J Rheumatol 2002;29:1041-8 KIM DUPREE JONES, CAROL S. BURCKHARDT, SHARON R. CLARK, ROBERT M. BENNETT, and KATHLEEN M. POTEMPA From the Schools of Nursing and Medicine at The Oregon Health and Science University, Portland, Oregon, USA. Supported by an Individual National Research Service Award (#1F31 NR07337-01A1) from the National Institutes of Health, a doctoral dissertation grant (#2324938) from the Arthritis Foundation, and funds from the Oregon Fibromyalgia Foundation. K.D. Jones, RN, PhD, Assistant Professor, School of Nursing; C.S. Burckhardt, RN, PhD, Professor, School of Nursing, Assistant Professor (Research), School of Medicine; S.R. Clark, RN, PhD, Associate Professor, School of Nursing, Assistant Professor (Research), School of Medicine; R.M. Bennett, MD, FRCP, Professor, School of Medicine; K.M. Potempa, RN, DNSc, FAAN, Professor and Dean, School of Nursing. Address reprint requests to Dr. K. Dupree Jones, School of Nursing, Mail Code SN-5S, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA. E-mail: joneskim@ohsu.edu Submitted March 13, 2001; revision accepted November 6, 2001. ABSTRACT. Objective. To determine the effectiveness of a muscle strengthening program compared to a stretching program in women with fibromyalgia (FM). Methods. Sixty-eight women with FM were randomly assigned to a 12 week, twice weekly exercise program consisting of either muscle strengthening or stretching. Outcome measures included muscle strength (main outcome variable), flexibility, weight, body fat, tender point count, and disease and symptom severity scales. Results. No statistically significant differences between groups were found on independent t tests. Paired t tests revealed twice the number of significant improvements in the strengthening group compared to the stretching group. Effect size scores indicated that the magnitude of change was generally greater in the strengthening group than the stretching group. Conclusion. Patients with FM can engage in a specially tailored muscle strengthening program and experience an improvement in overall disease activity, without a significant exercise induced flare in pain. Flexibility training alone also results in overall improvements, albeit of a lesser degree. (J Rheumatol 2002;29:1041-8) Key Indexing Terms: FIBROMYALGIA EXERCISE MUSCLE STRENGTHENING FLEXIBILITY