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C F S
- Information International Fatigue and CFS/ FM
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What is Fatigue ?
A comprehensive review of
fatigue in neurological disorders, definitely worth a read, chaudhuri.behan.04.txt, chaudhuri.behan04.txt, chaudhuri.behan04.pdf. Fatigue is a well-known phenomenon in both
central and peripheral neurological disorders, zwarts.etal07.txt,
zwarts.etal07.pdf. Enigma of Fatigue
The enigma of fatigue has been
named "the black hole of medicine", Eidelman, 2003, Eidelman, 2003 (pdf). Regional prevalence of fatiguing illnesses
in the Central Fatigue in CFS/ FM
An increasing number of studies
document central fatigue in CFS (as opposed to peripheral/muscle
fatigue),
Georgiades et al., 2003. Weight,
BMI is not correlated with fatigue in CFS, schur.etal07.txt,
schur.etal07.pdf. Rating of Fatigue
Dr. Jason's group has studied
ways of rating fatigue, comparing the Fatigue Scale and the Fatigue Severity
Scale, Taylor et al., 2000, and Friedberg & Jason, 2003. A study found diurnal rhythmicity in pain, stiffness,
and fatigue in patients with fibromyalgia, bellamy.etal04.txt. The assessment of fatigue - A
practical guide for clinicians and researchers, dittner.etal04.txt,
dittner.etal04.pdf. The instrument(s) used to
measure fatigue: Fatigue after brain injury: initial reliability study of the
BNI Fatigue Scale, borgaro.etal04.txt. Post-exertional Fatigue
Many
studies have stressed the importance of PE-malaise, including my own study, andersen.etal07.txt, andersen.etal07.pdf. One exercise test is not
enough to test for PE-malaise, vanNess.etal07.txt,
vanNess.etal07.pdf. Testing for fatigue has
important implications: the legal and scientific bases on which an exercise
stress test can provide medically acceptable evidence of disability for the CFS
patient, ciccolella.etal07.txt, ciccolella.etal.07.txt, ciccolella.etal07.pdf. Treating Fatigue
The treatment options for
fatigue in FM were reviewed,
Guymer & Clauw, 2002. The use of a narcolepsy drug
Modafinil in CFS,
Cochran, 2001, and in FM, letter, Schaller & Behar, 2001. A pilot study
recommends dexamphetamine for CFS,
Olson et al., 2002. Ginseng has
no obvious effect on chronic fatigue, hartz.etal04.txt. Fatigue in MS
Many doctors who treat both CFS
and Multiple Sclerosis (MS) patients have noticed a similarity between the fatigue described by the two patient categories. MS
patients suffer from severe fatigue, press, MS, fatigue, 2001. A 2001-study reviews
treatment of fatigue in MS, Comi
et al., 2001 (pdf). One study
tests 1-carnitine and amantadine for MS fatigue, thomassini.etal04.txt. Fatigue in multiple sclerosis: an
example of cytokine mediated sickness behaviour?, heesen.etal06.txt. Fatigue in MS: association with disease-related, behavioural and
psychosocial factors, trojan.etal07.txt. Fatigue in Cancer
Depression, fatigue and
cognitive dysfunction are all common symptoms in cancer but poorly
understood,
Valentine & Meyers, 2001. Dutch researchers
compared the fatigue in disease-free cancer patients with that of CFS
patients,
Servaes et al., 2001. and Servaes et al., 2002. Recently Dr. Bennett concluded that CRF appears closely related to CFS.
These findings raise the emergent hypothesis of a conserved neurobehavioral symptom
complex, which results from diverse triggering insults, bennett.etal07.txt, bennett.etal07.pdf.
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