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C F S
- Information International Hypothesis:
Oxidative Stress
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Oxidative Stress
The suggestion that enzyme deficiency
in CFS cause 'oxidative stress' was raised some years ago, richards.etal00.txt, keenoy.etal01.txt,
keenoy.etal01.pdf , fulle.etal00.txt, fulle.etal.00.txt. Modification of the functional capacity of sarcoplasmic reticulum
membranes, fulle.etal03.txt, fulle.etal03.pdf. Specific correlations
between muscle oxidative stress and CFS: a working hypothesis, fulle.etal08.txt, fulle.etal08.pdf.
The
Oxidative stress has also been suggested as the cause of FM, galeotti.etal01.txt. The finding of increased pentosidine levels in FM blood is also an indicator of oxidative stress, hein.franke02.txt. More evidence to link FM with disturbance in the oxidant/anti-oxidant system, bagis.etal03.txt. The Belgian CFS research team combining current knowledge on immune deregulation, RNAse disturbance and NO production presents a hypothesis, nijs.etal04.txt, nijs.etal04.pdf. Oxidative stress might reduce essential fatty acids in erythrocyte membranes of CFS patients, nijs.demeirleir04.txt, nijs.demeirleir04.pdf. Researchers in Lower serum zinc in CFS: Relationships to immune dysfunctions and relevance for the oxidative stress status in CFS, maes.etal05.txt, maes.etal05.pdf. Also, decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum Zinc and defects in T cell activation, maes.etal06.txt.
Antioxidant
status, lipid peroxidation and NO in fibromyalgia: etiologic and therapeutic
concerns, ozgocmen.etal05.txt. Current
concepts in the pathophysiology of fibromyalgia: the potential role of
oxidative stress and nitric oxide, ozgocmen.etal.05.txt. Oxidative
stress on erythrocyte maturation implies immature cells (stomatocytes), richards.etal07.txt, richards.etal07.pdf. Calcium
Channel Disturbance
Disturbances in ion channel functioning has been hypothesized, chaudhuri.etal00.txt, and with a possible link to deregulation
of the RNaseL pathway, nijs.etal01.txt. An Italian paper studied intracellular Ca and Mg in FM, magaldi.etal00.txt.
The Belgian researchers continue their work, relating channel problems
with RNase L cleavage, nijs.etal03.txt, nijs.etal03.pdf. Disturbance
of Mitochondrial functioning
A loss of mitochondrial activity is
characteristic in ageing and in fatigue states. Dr. Nicolson’s team suggested that
nutritional supplements may help mitochondrial functioning, agadjanyan.etal03.txt. A study on muscle fibres
in FM found low numbers of mitochondrias, and evidence of DNA fragmentation, sprott.etal04.txt. More evidence is accumulating in relation
to mitochondrial dysfunctioning as the cause of most (if not all) chronic diseases,
letter.fiddian-green04.txt. Use of phosphocreatine kinetics to
determine the influence of creatine on muscle mitochondrial respiration in
vivo, smith.etal04.txt, smith.etal04.pdf.
Acute phase phospholipids
related to the cardiolipin of mitochondria in the sera of patients with
chronic fatigue syndrome (CFS), hokama.etal08.txt,
hokama.etal08.pdf. Disturbances of NO Metabolism
Dr. Marty Pall has published multiple papers on NO metabolism as the cause of CFS and other syndromes, summed in his book, pall06.book.txt. Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO- cycle, pall07.txt, pall07.pdf. Elevated
protein carbonyls, smirnova.pall03.txt. NO can be produced in minute quantities during passive exercise,
which may relieve symptoms in FM and CFS, sackner.etal04.txt, sackner.etal04.pdf. Does NO trigger central sensitization? nijs.etal05.txt, nijs.etal05.pdf. Antiviral pathway deregulation of CFS induces NO production in immune
cells that precludes a resolution of the inflammatory response, fremont.etal06.txt.
No
association between the Glu298Asp polymorphism of the endothelial NO-synthase
gene and FM, alasehirli.etal06.txt. Belgian researchers: Not in the mind of
neurasthenic lazybones but in the cell nucleus: patients with CFS have
increased production of nuclear factor
kappa beta, maes.etal.07.txt, Not in the mind
but in the cell: increased production of cyclo-oxygenase-2 and inducible NO
synthase in CFS, maes.etal07.txt. |
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