Say NO to fibromyalgia and chronic fatigue syndrome: an alternative and
complementary therapy to aerobic exercise.

Med Hypotheses. 2004;63(1):118-23.

Marvin A. Sackner [*], Emerance M. Gummels and Jose A. Adams

Mt. Sinai Medical Center of Greater Miami, Division of
Pulmonary Disease and Critical Care Medicine and Department of
Neonatology, Miami Beach, FL 33140, USA

[*] Corresponding author. Tel.: +305-532-6329; fax: +305-532-0938 E-Mail:
mailto:artchive@msn.com

Received 28 January 2004;  accepted 31 January 2004.  Available online 15
April 2004.

NLM Citation: PMID: 15193362


Abstract:
Increased shear stress to the endothelium increases activity of
endothelial nitric oxide synthase (eNOS) with subsequent release of small
quantities (nMol) of nitric oxide (NO) into the circulation. It occurs
during moderate aerobic exercise mostly as a result of laminar shear
stress and with whole body, periodic acceleration as a result of
pulsatile shear stress.

The latter is administered by means of a new, non-invasive, passive
exercise device. Moderate exercise has long been known to alleviate the
symptoms of fibromyalgia and chronic fatigue syndrome and in the current
study, whole body, periodic acceleration did as well.

Since NO through action of eNOS has potent anti-inflammatory properties
mainly by suppressing nuclear factor kappabeta activity, it is
hypothesized that both diseases have chronic inflammation as their basis.

Whole body periodic acceleration can be applied separately or
supplementary to aerobic exercise in the treatment of fibromyalgia and
chronic fatigue syndrome.