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C F S
- Information International Irritable
Bowel Syndrome IBS
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Irritable Bowel Syndrome - IBS
A recent attempt to address IBS
classification, walter.etal04.txt. Abnormal forebrain activity in IBS seen
by MRI, kwan.etal05.txt. A Medscape review on the diagnosis of IBS, using the
Rome-criteria,
Ringel & Drossman, 2000. In NEJM a comprehensive
review of IBS was presented,
Horwitz & Fisher, 2001. A comprehensive
Medscape IBS resource has opened, resource, Medscape, IBS, 2002. Two 2003-Medscape articles sums
up the interesting new research on serotonin receptors in the gut, ibs.medscape03.htm and ibs.medscape.03.htm. A third article cites recent results on
familiar aggregation,
ibs.familiar.aggr03.txt. A query index to measure illness severity in IBS and
FM was suggested,
Sperber et al., 2000. Many IBS patients also suffer from rectal pain, news, rectal pain, 1999. IBS - Overlap with CFS/FM
There is great overlap between
CFS/FM and IBS,
Barton et al., 1999, Sperber et al., 1999, Azpiroz et al., 2000, and a Turkish
study,
Canataroglu et al., 2001. One abstract, Sydney
2001 dealt with gut motility in CFS confirming the overlap, Burnet & Chatterton, 2001. Co-existence of both FM and IBS results in worse
conditions, Chang et al., 1999 and Lubrano et al., 2001. Overlap with migraine, FM and depression, cole.etal06.txt. Comorbidity
of MD disorder with IBS is NOT Influenced by heredity, whitehead07.txt. Autonomic Dysfunction
IBS is most likely the result
of a complicated interaction between the brain, the nervous system, various
organs, the musculosceletal system, the HPA axis and serotonin, Mayer et al., 1998 and Gervais, 1999. An Italian
study found no visceral hypersensivity in FM, Pace et al., 2001, but a Swedish
study found exaggerated sensory response in IBS, IBS, press, 2001. A 2002-paper
refered to central sensitization as a key to IBS, Verne & Price, 2002. A press news, referring to Australian research, published
that brain origin of the IBS syndrome has been found, IBS, brain link, 2002. Stress induced exaggeration of the
neuroendocrine response, which may increase IBS symptoms, posserud.etal04.txt. Alteration of the spinal
modulation of nociceptive processing in patients with IBS, coffin.etal04.txt. Drug Treatments
Drug treatment for
constipation-dominant IBS is emerging, here Tegaserod [Zelmac], Prather et al., 2000, and news, Zelmac, 2000. Alosetron
[Lotronex] was approved Feb 2000,
news, Alosetron, 2000. An optimistic outlook
for this treatment was aired in a Medscape paper, Isselbacher, 2000. However, a report later in 2000 warned
against serious side-effects from the drug, press, Lotronex, 2000, and FDA, warning, Lotronex, 2000. The newest information on constirpation
dominant IBS, brunton04.html. A systematic review Sep 00 of 70 articles on drug
treatment for IBS revealed only 3 significant studies, news studies, IBS, 2000. Interestingly, one of these drugs (granisetron, a
5-HT3 receptor antagonist) is now reported useful for treating 4 of 5
patients with CFS in a Dutch study, the.etal03.txt.
This very preliminary result is commented in the editorial, editorial.granisetron03.txt. A review on the use of 5-HT3 receptor
antagonist, suggest that they may be beneficial for bowel disorders, costall.naylor04.txt. Bacteria, Inflammatory Markers
IBS has been suggested to
involve overgrowth of bacteria in the intestines, Pimentel et al., 2001. One study
demonstrated bacterial abnormalities in CFS, Butt et al., 2001. A lactulose breath test is based on such
findings, pimentel.etal04.txt. An editorial
discusses bacterial overgrowth as the basis for understanding IBS, lin04.txt. |
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