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Sjögren's  Syndrome

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Sjögren's Syndrome

Sjogren syndrome (SS), is the second most common autoimmune rheumatic disease. The symptoms are keratoconjunctivitis sicca and xerostomia (dry eyes and mouth) resulting from immune lymphocytes that infiltrate the lacrimal and salivary glands,  Fox et al., 2000.  On autoantibody production and T-cell clones in Sjögren's Syndrome, see  Fauci, 2000.
 

Overlap with Sjögren's Syndrome

Overlap between FM and Sjogren's Syndrome includes the presence of antibodies and possible common pathophysiology. However, a 1999-study did not find increased sicca eyes in FM,  Gunaydin et al., 1999,  and a 2000-study found only a minority of patients with Sjogren's to have FM,  Giles & Isenberg, 2000.  Italian studies found clinical evidence for a moderate overlap between FM and SS,  Ostuni et al., 2002,  and  Ostuni et al., 2002.

A 2001-study from New Jersey concludes that a subset of patients with CFS may have primary SS,  Sirois & Natelson, 2001,  while a 2002-UK study found CFS/FM patients with sicca symptoms does not fulfil Sjogren criteria,  Price & Venables, 2002.  Collecting saliva for diagnostic procedures should be standardized,  Nederfors et al., 2002.

According to a Finish study, the fatigue present with sicca symptoms (with or without Sjogren's) is only partly explained by common diseases indicators, most likely neuroendocrine factors are involved,  Tensing et al., 2001.
 

Pain in Sjögren's Syndrome

A Swedish study deals with the overlap of 2 different kinds of pain, one being FM-pain,  Strombeck et al.,2001.  Myositis and muscle pain (FM) in Sjogren is common,  Lindvall et al., 2002.
 

Sjögren's Treatment

Trials with treatment of Sjögren's Syndrome with interferon alpha have started,  July 1999, Amarillo Biosciences.

An ACR-review on "the state of the art" of Sjogren's Syndrome,  Borenstein, 1999.

For a recent review, Treatment Updates - Sjögren Syndrome:  Fox, 2000.
 


 
 
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